What is the Research Study About?
While safe and effective for the majority of patients, Proton Pump Inhibitor (PPI) therapy for GERD fails in 40% of children. When this happens, the only other option that doctors have to manage GERD is surgery, which comes with inherent risk. What if we could predict which patients were likely to fail PPI therapy and adjust their treatment accordingly? This is the goal of Precision Medicine, which accounts for factors that influence response to drug therapy including individual variability in genes, environment, and lifestyle allowing doctors and researchers to predict more accurately which treatment and prevention strategies will be most effective for an individual. In this study we will establish the most effective PPI dose for an individual, based on genetic variation that influences how PPIs are metabolized by the body.
What is Precision Medicine?
In conventional dosing (Figure 1A), PPI dose is based primarily on weight and is initially determined from population studies to maximize response for most people (about 60%). This means that for 40% of the population, the drug doesn’t work as expected. In genotype-guided dosing, the dose of the drug is adjusted based on the genetics of the individual theoretically maximizing response in up to 100% of the individuals (Figure 1B).